Devesh Tewari Lab - Xanthohumol for Human Malignancies: Chemistry,

Journal article

V. Harish, Effi Haque, M. Śmiech, Hiroaki Taniguchi, Sarah Jamieson, Devesh Tewari, A. Bishayee
International Journal of Molecular Sciences, 2021

Semantic Scholar DOI PubMedCentral PubMed

Cite

APA Click to copy
Harish, V., Haque, E., Śmiech, M., Taniguchi, H., Jamieson, S., Tewari, D., & Bishayee, A. (2021). Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets. International Journal of Molecular Sciences.

Chicago/Turabian Click to copy
Harish, V., Effi Haque, M. Śmiech, Hiroaki Taniguchi, Sarah Jamieson, Devesh Tewari, and A. Bishayee. “Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets.” International Journal of Molecular Sciences (2021).

MLA Click to copy
Harish, V., et al. “Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets.” International Journal of Molecular Sciences, 2021.

BibTeX Click to copy

@article{v2021a,
  title = {Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets},
  year = {2021},
  journal = {International Journal of Molecular Sciences},
  author = {Harish, V. and Haque, Effi and Śmiech, M. and Taniguchi, Hiroaki and Jamieson, Sarah and Tewari, Devesh and Bishayee, A.}
}

Abstract

Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.