Devesh Tewari Lab - Himalayan Ficus palmata L. Fruit Extract Showed In

Journal article

Devesh Tewari, Pawan Gupta, Sweta Bawari, A. Sah, D. Barreca, Hamid Reza Khayat Kashani, Hamid Reza Khayat Kashani
Plants, 2021

Semantic Scholar DOI PubMedCentral PubMed

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APA Click to copy
Tewari, D., Gupta, P., Bawari, S., Sah, A., Barreca, D., Kashani, H. R. K., & Kashani, H. R. K. (2021). Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors. Plants.

Chicago/Turabian Click to copy
Tewari, Devesh, Pawan Gupta, Sweta Bawari, A. Sah, D. Barreca, Hamid Reza Khayat Kashani, and Hamid Reza Khayat Kashani. “Himalayan Ficus Palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors.” Plants (2021).

MLA Click to copy
Tewari, Devesh, et al. “Himalayan Ficus Palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors.” Plants, 2021.

BibTeX Click to copy

@article{devesh2021a,
  title = {Himalayan Ficus palmata L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors},
  year = {2021},
  journal = {Plants},
  author = {Tewari, Devesh and Gupta, Pawan and Bawari, Sweta and Sah, A. and Barreca, D. and Kashani, Hamid Reza Khayat and Kashani, Hamid Reza Khayat}
}

Abstract

Analgesic drugs like morphine and non-steroidal anti-inflammatory drugs exhibit several harmful effects. Here, we show for the first time the analgesic activity of Ficus palmata L. fruit extract (FPFE) on different analgesic rat models along with the in silico studies of some of the main phytochemicals of this plant. We performed in vivo pain models, along with in silico docking studies against the active site of COX-2 protein and mu-opioid receptors. A significant (p < 0.05) analgesic effect of FPFE was observed, and it was found that rutin has good pose and score as compared to diclofenac and morphinan antagonist (X-ligand), and psoralen has binding affinity almost equal to diclofenac, but a lower binding affinity as compared to rutin. The results proved that F. palmata fruits have the potential to ameliorate painful conditions.