Journal article
Laxman Singh, Shikha Sharma, Suowen Xu, Devesh Tewari, Jian-Mei Fang
Molecules, 2021
Molecules, 2021
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DOI
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APA
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Singh, L., Sharma, S., Xu, S., Tewari, D., & Fang, J.-M. (2021). Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review. Molecules.
Chicago/Turabian
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Singh, Laxman, Shikha Sharma, Suowen Xu, Devesh Tewari, and Jian-Mei Fang. “Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review.” Molecules (2021).
MLA
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Singh, Laxman, et al. “Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review.” Molecules, 2021.
BibTeX Click to copy
@article{laxman2021a,
title = {Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review},
year = {2021},
journal = {Molecules},
author = {Singh, Laxman and Sharma, Shikha and Xu, Suowen and Tewari, Devesh and Fang, Jian-Mei}
}
Abstract
Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Atherosclerosis is a comprehensive term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large- and medium-sized arteries, causing decreased vascular-wall elasticity and lumen diameter. Atherosclerotic cerebro-cardiovascular disease has become a major concern for human health in recent years due to its clinical sequalae of strokes and heart attacks. Curcumin concoction treatment modulates several important signaling pathways related to cellular migration, proliferation, cholesterol homeostasis, inflammation, and gene transcription, among other relevant actions. Here, we provide an overview of curcumin in atherosclerosis prevention and disclose the underlying mechanisms of action of its anti-atherosclerotic effects.