Journal article
H. Khan, Surrya Amin, Devesh Tewari, S. Nabavi, A. Atanasov
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2018
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2018
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APA
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Khan, H., Amin, S., Tewari, D., Nabavi, S., & Atanasov, A. (2018). Plant derived glycosides with α-glucosidase inhibitory activity: current standing and future prospects. Endocrine, Metabolic &Amp; Immune Disorders - Drug Targets.
Chicago/Turabian
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Khan, H., Surrya Amin, Devesh Tewari, S. Nabavi, and A. Atanasov. “Plant Derived Glycosides with α-Glucosidase Inhibitory Activity: Current Standing and Future Prospects.” Endocrine, Metabolic & Immune Disorders - Drug Targets (2018).
MLA
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Khan, H., et al. “Plant Derived Glycosides with α-Glucosidase Inhibitory Activity: Current Standing and Future Prospects.” Endocrine, Metabolic &Amp; Immune Disorders - Drug Targets, 2018.
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@article{h2018a,
title = {Plant derived glycosides with α-glucosidase inhibitory activity: current standing and future prospects.},
year = {2018},
journal = {Endocrine, Metabolic & Immune Disorders - Drug Targets},
author = {Khan, H. and Amin, Surrya and Tewari, Devesh and Nabavi, S. and Atanasov, A.}
}
Abstract
The α-glucosidase (EC 3.2.1.20), a calcium-containing intestinal enzyme which is positioned in the cells which cover the intestinal microvilli brush border. The carbohydrates require metabolism by α-glucosidase before being absorbed into the small intestine, and as a result this enzyme represents a significant drug target for the effective management of diabetes. There are few α-glucosidase inhibitors in the clinical practice that are challenged by several limitations. Thus, new effective and safe therapeutic agents in this class are required. In this regard, plant secondary metabolites are a very promising source to be investigated. Herein in this review, we have focused on the preclinical studies on various glycosides with in vitro α-glucosidase inhibitory activity. The surveyed literature revealed marked inhibitory profile of various glycosides, and some of them were extremely potent relatively to the standard, acarbose. Therefore, these glycosides are strong candidates for further more detailed studies to ascertain their clinical potential and for effective contribution in effective management of diabetes, where multiple targets are required to address.